Mouse PGLYRP1 protein (Recombinant) (N-His) (STJP009214)
SPECIFICATIONS
HostE.coli
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse PGLYRP1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | Pglyrp1 |
| Gene ID | 21946 |
| Uniprot ID | PGRP1_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Val41-Glu182 |
Additional Info
| Function | Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Also promotes the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor. |
| Protein Name | Peptidoglycan Recognition Protein 1Cytokine Tag7Peptidoglycan Recognition Protein ShortPgrp-S |
| Database Links | Reactome: R-MMU-6798695Reactome: -MMU-6803157 |
| Cellular Localisation | CytoplasmSecretedExists In Both Soluble And Membrane-Associated Forms |
| Alternative Protein Names | Peptidoglycan Recognition Protein 1 proteinCytokine Tag7 proteinPeptidoglycan Recognition Protein Short proteinPgrp-S proteinPglyrp1 proteinPglyrp proteinPgrp proteinPgrps proteinTag7 protein |
Information sourced from Uniprot.org