Mouse OCT4 (Octamer Binding Transcription Factor 4) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017558)

Mouse OCT4 (Octamer Binding Transcription Factor 4) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017558)

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STJE0017558
£456.50 - £625.50
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Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description : This OCT4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Pou5f1
Gene ID: 18999
Uniprot ID: PO5F1_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed the totipotent and pluripotent stem cells of the pregastrulation embryo. Also expressed in primordial germ cells and in the female germ line. Absent from adult tissues.
Post Translational Modifications Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression. Ubiquitinated.undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation. ERK1/2-mediated phosphorylation at Ser-106 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-228 and Ser-229 decrease DNA-binding and alters ability to activate transcription. JNK1/2-mediated phosphorylation at Ser-347 promotes proteasomal degradation.
Function Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Protein Name Pou Domain - Class 5 - Transcription Factor 1
Nf-A3
Octamer-Binding Protein 3
Oct-3
Octamer-Binding Protein 4
Oct-4
Octamer-Binding Transcription Factor 3
Otf-3
Database Links
Cellular Localisation Cytoplasm
Nucleus
Expressed In A Diffuse And Slightly Punctuate Pattern
Colocalizes With Mapk8 And Mapk9 In The Nucleus
Alternative ELISA Names Pou Domain - Class 5 - Transcription Factor 1 ELISA kit
Nf-A3 ELISA kit
Octamer-Binding Protein 3 ELISA kit
Oct-3 ELISA kit
Octamer-Binding Protein 4 ELISA kit
Oct-4 ELISA kit
Octamer-Binding Transcription Factor 3 ELISA kit
Otf-3 ELISA kit
Pou5f1 ELISA kit
Oct-3 ELISA kit
Oct-4 ELISA kit
Otf-3 ELISA kit
Otf3 ELISA kit
output

Information sourced from Uniprot.org

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