Mouse NUCB2 (Nucleobindin 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017529)
SPECIFICATIONS
General Information
| Short Description | This NUCB2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 12.5pg/mL |
| Detection Limit | 31.2-2000pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | Nucb2 |
| Gene ID | 53322 |
| Uniprot ID | NUCB2_MOUSE |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma or other biological fluids. |
Additional Info
| Tissue Specificity | Found in liver, heart, thymus, muscle, intestine, kidney, lung, spleen and throughout the brain, in cerebral cortex, hippocampus, hypothalamus and medulla oblongata. Nucb2 and necdin levels were higher in postmitotic neurons. |
| Post Translational Modifications | |
| Function | Calcium-binding protein which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3. Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion. |
| Protein Name | Nucleobindin-2Dna-Binding Protein NefaPrepronesfatin Cleaved Into - Nesfatin-1 |
| Database Links | |
| Cellular Localisation | CytoplasmPerikaryonEndoplasmic ReticulumGolgi ApparatusNucleus EnvelopeMembranePeripheral Membrane ProteinSecretedIn Dendrites And Perikarya Of Brain NeuronsAbundant In The Er Cisternae And Nuclear EnvelopeBut Not Detected In GolgiMitochondria Or Nucleoplasm In NeuronsIn Cell CultureCytoplasmic And SecretedNesfatin-1: Secreted |
| Alternative ELISA Names | Nucleobindin-2 ELISA kitDna-Binding Protein Nefa ELISA kitPrepronesfatin Cleaved Into - Nesfatin-1 ELISA kitNucb2 ELISA kitNefa ELISA kit |
| output |
Information sourced from Uniprot.org