| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Mouse NTRK3/TrkC-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | Ntrk3 |
| Gene ID: | 18213 |
| Uniprot ID: | NTRK3_MOUSE |
| Immunogen Region: | Val530-Gly825 |
| Immunogen: | Mus musculus (Mouse) |
| Post Translational Modifications | Ligand-mediated auto-phosphorylation. |
| Function | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. |
| Protein Name | Nt-3 Growth Factor ReceptorGp145-TrkcTrk-CNeurotrophic Tyrosine Kinase Receptor Type 3Trkc Tyrosine Kinase |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-388844Reactome: -MMU-6811558Reactome: -MMU-9034013Reactome: -MMU-9034793Reactome: -MMU-9603381 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Nt-3 Growth Factor Receptor proteinGp145-Trkc proteinTrk-C proteinNeurotrophic Tyrosine Kinase Receptor Type 3 proteinTrkc Tyrosine Kinase proteinNtrk3 proteinTrkC protein |
Information sourced from Uniprot.org