| Tissue Specificity | EXpressed in brain, in all layers of the cerebellum, in pyramidal cells of the Ammon horn and in Purkinje cells (at protein level). Expressed in osteoclasts, leukocytes, kidney, liver and lung. |
| Post Translational Modifications | N-glycosylation is required for the function. |
| Function | NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. |
| Protein Name | Nadph Oxidase 4Kidney Oxidase-1Kox-1Kidney Superoxide-Producing Nadph OxidaseRenal Nad(Ph-OxidaseSuperoxide-Generating Nadph Oxidase 4 |
| Database Links | Reactome: R-MMU-3299685 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinCell MembraneCell JunctionFocal AdhesionNucleus |
| Alternative ELISA Names | Nadph Oxidase 4 ELISA kitKidney Oxidase-1 ELISA kitKox-1 ELISA kitKidney Superoxide-Producing Nadph Oxidase ELISA kitRenal Nad(Ph-Oxidase ELISA kitSuperoxide-Generating Nadph Oxidase 4 ELISA kitNox4 ELISA kitRenox ELISA kit |
| output | |
Information sourced from Uniprot.org
