| Function | A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. |
| Protein Name | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3Nherf-3Cftr-Associated Protein Of 70 KdaNa(+/H(+ Exchanger Regulatory Factor 3Na/Pi Cotransporter C-Terminal-Associated Protein 1Napi-Cap1Pdz Domain-Containing Protein 1Sodium-Hydrogen Exchanger Regulatory Factor 3 |
| Cellular Localisation | MembranePeripheral Membrane ProteinCell MembraneLocalized In The Brush Border Membrane Of Renal Proximal Tubule CellsAssociated With Peripheral MembranesLocalizes To The Apical Compartment Of Proximal Cells And To Sinusoidal Liver Membranes |
| Alternative Protein Names | Na(+/H(+ Exchange Regulatory Cofactor Nhe-Rf3 proteinNherf-3 proteinCftr-Associated Protein Of 70 Kda proteinNa(+/H(+ Exchanger Regulatory Factor 3 proteinNa/Pi Cotransporter C-Terminal-Associated Protein 1 proteinNapi-Cap1 proteinPdz Domain-Containing Protein 1 proteinSodium-Hydrogen Exchanger Regulatory Factor 3 proteinPdzk1 proteinCap70 proteinNherf3 protein |
Information sourced from Uniprot.org
