Mouse MME/Neprilysin/CD10 protein (Recombinant) (N-His) (STJP020331)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse MME/CD10 Protein is produced by Expi293 cells expression system. The target protein is expressed with sequence (Tyr52-Trp750) of Mouse MME/CD10 (Accession #Q61391) fused with His tag at the N-terminus.
General Information
| Short Description | Recombinant-Mouse MME/Neprilysin/CD10-N-His protein was developed in hek293 cells using the region Tyr52-Trp750. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Mme |
| Gene ID | 17380 |
| Uniprot ID | NEP_MOUSE |
| Immunogen | Recombinant Mouse MME/CD10 Protein is produced by Expi293 cells expression system. The target protein is expressed with sequence (Tyr52-Trp750) of Mouse MME/CD10 (Accession #Q61391) fused with His tag at the N-terminus. |
| Immunogen Region | Tyr52-Trp750 |
Additional Info
| Post Translational Modifications | Myristoylation is a determinant of membrane targeting. Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity. |
| Function | Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of the atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. |
| Protein Name | NeprilysinAtriopeptidaseEnkephalinaseNeutral Endopeptidase 24.11NepNeutral EndopeptidaseSkin Fibroblast ElastaseSfeCd Antigen Cd10 |
| Database Links | Reactome: R-MMU-2022377Reactome: -MMU-5578768Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Neprilysin proteinAtriopeptidase proteinEnkephalinase proteinNeutral Endopeptidase 24.11 proteinNep proteinNeutral Endopeptidase proteinSkin Fibroblast Elastase proteinSfe proteinCd Antigen Cd10 proteinMme protein |
Information sourced from Uniprot.org