| Short Description : | Recombinant-Mouse Mesothelin/MSLN-C-His protein was developed in hek293 cells using the region Asp298-Ser600. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Mouse Mesothelin/MSLN at 2 Mu g/mL (100 Mu L/well) can bind Human CA125 with a linear range of 0.01-0.72 ng/mL. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | Msln |
| Gene ID: | 56047 |
| Uniprot ID: | MSLN_MOUSE |
| Immunogen: | Recombinant Mouse Mesothelin/MSLN Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp298-Ser600) of mouse MSLN/Mesothelin (Accession #NP_061345.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Asp298-Ser600 |
| Immunogen Sequence: | DAEQKACPPGKEPYKVDEDL IFYQNWELEACVDGTMLARQ MDLVNEIPFTYEQLSIFKHK LDKTYPQGYPESLIQQLGHF FRYVSPEDIHQWNVTSPDTV KTLLKVSKGQKMNAQAIALV ACYLRGGGQLDEDMVKALGD IPLSYLCDFSPQDLHSVPSS VMWLVGPQDLDKCSQRHLGL LYQKACSAFQNVSGLEYFEK IKTFLGGASVKDLRALSQHN VSMDIATFKRLQVDSLVGL |
| Post Translational Modifications | Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. |
| Function | Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation. |
| Protein Name | MesothelinPre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating FactorMpf - Mesothelin - Cleaved Form |
| Database Links | Reactome: R-MMU-163125Reactome: -MMU-381426Reactome: -MMU-8957275 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorGolgi ApparatusMegakaryocyte-Potentiating Factor: Secreted |
| Alternative Protein Names | Mesothelin proteinPre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating Factor proteinMpf - Mesothelin - Cleaved Form proteinMsln proteinMes proteinMpf protein |
Information sourced from Uniprot.org
