Mouse MCUB protein (Recombinant) (C-His) (STJP014912)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse MCUB-C-His protein was developed from e.coli and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | Mcub |
| Gene ID | 66815 |
| Uniprot ID | MCUB_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Met1-Gly228 |
Additional Info
| Function | Negative regulator of the mitochondrial calcium uniporter (MCU), a channel that mediates calcium uptake into the mitochondrial matrix. MCUB is required to limit mitochondrial calcium overload during stress. Acts as a dominant-negative regulator that displaces MCU from the functional uniplex complex and thereby decreases the association of calcium sensors MICU1 and MICU2, preventing channel gating. Mitochondrial calcium homeostasis plays key roles in mitochondrial metabolism. Acts as an important regulator of mitochondrial metabolism in response to stress in muscle cells: induced in response to fasting, leading to restrict mitochondrial calcium uptake, resulting in reprogramming of mitochondria toward fatty acid oxidation preference. Acts as a regulator of macrophage polarization during skeletal muscle regeneration: inhibition of mitochondrial calcium uptake drives differentiation of macrophages with anti-inflammatory profile, promoting the differentiation and fusion of satellite cells. |
| Protein Name | Calcium Uniporter Regulatory Subunit Mcub - MitochondrialMcubCoiled-Coil Domain-Containing Protein 109b |
| Database Links | Reactome: R-MMU-8949215Reactome: -MMU-8949664 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Calcium Uniporter Regulatory Subunit Mcub - Mitochondrial proteinMcub proteinCoiled-Coil Domain-Containing Protein 109b proteinMcub proteinCcdc109b protein |
Information sourced from Uniprot.org