Mouse MCL1 (Myeloid Cell Leukemia Sequence 1, Bcl2 Related) Sandwich ELISA Kit (STJE0010519)
SPECIFICATIONS
General Information
| Short Description | This MCL1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Mouse |
| Sensitivity | 0.056ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | Mcl1 |
| Gene ID | 17210 |
| Uniprot ID | MCL1_MOUSE |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment. Rapidly degraded in the absence of phosphorylation in the PEST region. Phosphorylated on Ser-140, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-140 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-140. Deubiquitinated by USP20.leading to increased stability. |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity. |
| Protein Name | Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 HomologBcl-2-Related Protein Eat/Mcl1 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinCytoplasmMitochondrionNucleusNucleoplasmCytoplasmicAssociated With Mitochondria |
| Alternative ELISA Names | Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 Homolog ELISA kitBcl-2-Related Protein Eat/Mcl1 ELISA kitMcl1 ELISA kit |
| output |
Information sourced from Uniprot.org