Mouse MADCAM1 protein (Recombinant) (N-His) (STJP009208)

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STJP009208
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse MADCAM1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Madcam1
Uniprot ID: MADCA_MOUSE
Immunogen Region: Gln22-Ser222
Immunogen: Mus musculus (Mouse)
Post Translational Modifications O-glycosylated.contains syalic acid. The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
Function Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Protein Name Mucosal Addressin Cell Adhesion Molecule 1
Madcam-1
Mmadcam-1
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Mucosal Addressin Cell Adhesion Molecule 1 protein
Madcam-1 protein
Mmadcam-1 protein
Madcam1 protein

Information sourced from Uniprot.org

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