| Tissue Specificity | |
| Post Translational Modifications | Contains hydroxylated asparagine residues. Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix. O-glycosylated on serine residues by POGLUT2 and POGLUT3. |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. |
| Protein Name | Latent-Transforming Growth Factor Beta-Binding Protein 1Ltbp-1Transforming Growth Factor Beta-1-Binding Protein 1Tgf-Beta1-Bp-1 |
| Database Links | Reactome: R-MMU-2129379Reactome: -MMU-2173789Reactome: -MMU-381426Reactome: -MMU-8957275 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative ELISA Names | Latent-Transforming Growth Factor Beta-Binding Protein 1 ELISA kitLtbp-1 ELISA kitTransforming Growth Factor Beta-1-Binding Protein 1 ELISA kitTgf-Beta1-Bp-1 ELISA kitLtbp1 ELISA kit |
| output | |
Information sourced from Uniprot.org
