| Short Description : | Recombinant-Active-Mouse KLK7-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications: | ELISA/WB |
| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity: | Measured by its ability to cleave the fluorogenic peptide substrate, McaRPKPVE-NvalWRK (Dnp)-NH2. The specific activity is >70 pmol/min/Mu g, as measured under the described conditions. |
| Gene Symbol: | Klk7 |
| Gene ID: | 23993 |
| Uniprot ID: | KLK7_MOUSE |
| Immunogen: | Mus musculus (Mouse) |
| Immunogen Region: | Gln22-Arg249 |
| Function | May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. |
| Protein Name | Kallikrein-7Serine Protease 6Stratum Corneum Chymotryptic EnzymeThymopsin |
| Database Links | Reactome: R-MMU-1474228 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Kallikrein-7 proteinSerine Protease 6 proteinStratum Corneum Chymotryptic Enzyme proteinThymopsin proteinKlk7 proteinPrss6 proteinScce protein |
Information sourced from Uniprot.org