Host: | E. coli |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Recombinant-Mouse KLB/Beta-klotho-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Gene Symbol: | Klb |
Gene ID: | 83379 |
Uniprot ID: | KLOTB_MOUSE |
Immunogen Region: | Ser86-Gly505 |
Immunogen: | Mus musculus (Mouse) |
Function | Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. |
Protein Name | Beta-KlothoBklBetaklothoKlotho Beta-Like Protein |
Database Links | Reactome: R-MMU-109704Reactome: -MMU-1257604Reactome: -MMU-1307965Reactome: -MMU-5654228Reactome: -MMU-5654712Reactome: -MMU-5654719Reactome: -MMU-5654720Reactome: -MMU-5654733Reactome: -MMU-5673001Reactome: -MMU-6811558 |
Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane Protein |
Alternative Protein Names | Beta-Klotho proteinBkl proteinBetaklotho proteinKlotho Beta-Like Protein proteinKlb proteinBetakl protein |
Information sourced from Uniprot.org