Mouse KITLG/SCF protein (Recombinant-Active) (Tag free) (STJP012833)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Active-Mouse KITLG/SCF-Tag free protein was developed from e.coli and has a target region of Tag free. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.2 Mu m filtered solution in PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 0.01 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | Kitlg |
| Gene ID | 17311 |
| Uniprot ID | SCF_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Lys26-Ala189 |
Additional Info
| Post Translational Modifications | A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain. |
| Function | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Protein Name | Kit LigandHematopoietic Growth Factor KlMast Cell Growth FactorMgfSteel FactorStem Cell FactorScfC-Kit Ligand Cleaved Into - Soluble Kit LigandSkitlg |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-1433557Reactome: -MMU-1433559Reactome: -MMU-5673001Reactome: -MMU-6811558Reactome: -MMU-9856649 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: CytoplasmCytoplasmCytoskeletonCell MembraneCell ProjectionLamellipodiumFilopodiumSoluble Kit Ligand: Secreted |
| Alternative Protein Names | Kit Ligand proteinHematopoietic Growth Factor Kl proteinMast Cell Growth Factor proteinMgf proteinSteel Factor proteinStem Cell Factor proteinScf proteinC-Kit Ligand Cleaved Into - Soluble Kit Ligand proteinSkitlg proteinKitlg proteinKitl proteinMgf proteinSl proteinSlf protein |
Information sourced from Uniprot.org