Mouse Interferon alpha/beta receptor 1/IFNAR1 protein (Recombinant) (C-hFc) (STJP020251)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse Interferon alpha/beta receptor 1/IFNAR1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu27-Thr429) of Mouse Interferon alpha/beta receptor 1/IFNAR1 (Accession #) fused with hF
General Information
| Short Description | Recombinant-Mouse Interferon alpha/beta receptor 1/IFNAR1-C-hFc protein was developed in hek293 cells using the region Glu27-Thr429. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Ifnar1 |
| Gene ID | 15975 |
| Uniprot ID | INAR1_MOUSE |
| Immunogen | Recombinant Mouse Interferon alpha/beta receptor 1/IFNAR1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu27-Thr429) of Mouse Interferon alpha/beta receptor 1/IFNAR1 (Accession #) fused with hF |
| Immunogen Region | Glu27-Thr429 |
| Immunogen Sequence | ENLKPPENIDVYIIDDNYTL KWSSHGESMGSVTFSAEYRT KDEAKWLKVPECQHTTTTKC EFSLLDTNVYIKTQFRVRAE EGNSTSSWNEVDPFIPFYTA HMSPPEVRLEAEDKAILVHI SPPGQDGNMWALEKPSFSYT IRIWQKSSSDKKTINSTYYV EKIPELLPETTYCLEVKAIH PSLKKHSNYSTVQCISTTVA NKMPVPGNLQVDAQGKSYVL KWDYIASADVLFRAQWLPG |
Additional Info
| Post Translational Modifications | Ubiquitinated. This leads to its internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex.this prevents receptor internalization and degradation. Probable ubiquitination sites have been identified in human, but are poorly conserved across species. Phosphorylated on serine residues in response to interferon binding.this promotes interaction with FBXW11 and ubiquitination. |
| Function | Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. |
| Protein Name | Interferon Alpha/Beta Receptor 1Ifn-R-1Ifn-Alpha/Beta Receptor 1Type I Interferon Receptor 1 |
| Database Links | Reactome: R-MMU-909733Reactome: -MMU-912694 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLate EndosomeLysosomeInterferon Binding Triggers Internalization Of The Receptor From The Cell Membrane Into Endosomes And Then Into Lysosomes |
| Alternative Protein Names | Interferon Alpha/Beta Receptor 1 proteinIfn-R-1 proteinIfn-Alpha/Beta Receptor 1 proteinType I Interferon Receptor 1 proteinIfnar1 proteinIfar proteinIfnar protein |
Information sourced from Uniprot.org