Tissue Specificity | Expressed on eosinophils and basophils. Also on B-cells. |
Post Translational Modifications | |
Function | Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. |
Protein Name | Interleukin-5 Receptor Subunit AlphaIl-5 Receptor Subunit AlphaIl-5r Subunit AlphaIl-5r-AlphaIl-5raCd Antigen Cd125 |
Database Links | Reactome: R-MMU-512988Reactome: -MMU-5673001Reactome: -MMU-912526 |
Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
Alternative ELISA Names | Interleukin-5 Receptor Subunit Alpha ELISA kitIl-5 Receptor Subunit Alpha ELISA kitIl-5r Subunit Alpha ELISA kitIl-5r-Alpha ELISA kitIl-5ra ELISA kitCd Antigen Cd125 ELISA kitIl5ra ELISA kitIl5r ELISA kit |
output | |
Information sourced from Uniprot.org