| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse IL4R-C-6His protein was developed from hek293 cells and has a target region of C-6His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its ability to inhibit the mIL-4-dependent proliferation of HT-2 mouse T cells. The ED50 for this effect is 0.5-2 Mu g/mL in the presence of 5 ng/mL of recombinant mouse IL-4 (Catalog: RP01161). |
| Gene Symbol: |
Il4r |
| Gene ID: |
16190 |
| Uniprot ID: |
IL4RA_MOUSE |
| Immunogen Region: |
Ile 26-Arg 233 |
| Immunogen: |
Recombinant Mouse IL4R Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile 26-Arg 233) of mouse IL4R (Accession #NP_001008700.1) fused with and a 6×His tag at the C-terminus. |
| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. Soluble IL4R can also be produced by proteolytic cleavage at the cell surface (shedding). |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. |
| Protein Name | Interleukin-4 Receptor Subunit AlphaIl-4 Receptor Subunit AlphaIl-4r Subunit AlphaIl-4r-AlphaIl-4raCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit AlphaSoluble Il-4 Receptor Subunit AlphaSoluble Il-4r-AlphaSil4ralpha/ProtIl-4-Binding ProteinIl4-Bp |
| Database Links | Reactome: R-MMU-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Interleukin-4 Receptor Subunit Alpha proteinIl-4 Receptor Subunit Alpha proteinIl-4r Subunit Alpha proteinIl-4r-Alpha proteinIl-4ra proteinCd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha proteinSoluble Il-4 Receptor Subunit Alpha proteinSoluble Il-4r-Alpha proteinSil4ralpha/Prot proteinIl-4-Binding Protein proteinIl4-Bp proteinIl4r proteinIl4ra protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
