Mouse IL31RA protein (Recombinant-Active) (C-hFc-His) (STJP012197)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Active-Mouse IL31RA-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. When recombinant mouse IL31RA is Immobilised at 5 µg/mL (100 µL/well) , recombinant mouse IL‑31 binds with an ED50 of 0.9-5.4 Mu g/mL. |
Target Information
| Gene Symbol | Il31ra |
| Gene ID | 218624 |
| Uniprot ID | IL31R_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Val19-Ser503 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. |
| Protein Name | Interleukin-31 Receptor Subunit AlphaIl-31 Receptor Subunit AlphaIl-31r Subunit AlphaIl-31r-AlphaIl-31raGlm-RMglm-RGp130-Like Monocyte ReceptorGp130-Like ReceptorNovel Cytokine Receptor 10Nr10Zcytor17 |
| Database Links | Reactome: R-MMU-6788467 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPresynaptic Cell MembraneCell ProjectionAxon |
| Alternative Protein Names | Interleukin-31 Receptor Subunit Alpha proteinIl-31 Receptor Subunit Alpha proteinIl-31r Subunit Alpha proteinIl-31r-Alpha proteinIl-31ra proteinGlm-R proteinMglm-R proteinGp130-Like Monocyte Receptor proteinGp130-Like Receptor proteinNovel Cytokine Receptor 10 proteinNr10 proteinZcytor17 proteinIl31ra proteinGlmr protein |
Information sourced from Uniprot.org