Function | Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors. |
Protein Name | Interleukin-17 Receptor EIl-17 Receptor EIl-17re |
Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: SecretedIsoform 4: CytoplasmIsoform 5: Cytoplasm |
Alternative Protein Names | Interleukin-17 Receptor E proteinIl-17 Receptor E proteinIl-17re proteinIl17re protein |
Information sourced from Uniprot.org