Recombinant Mouse IL-21 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 45-60kDa.

Mouse IL-21 protein (Recombinant) (No-Tag) (STJP002914)

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STJP002914
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Short Description :Recombinant-Mouse IL-21-No-Tag protein was developed in e.coli using the region His18-Ser146. For use in research applications.
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Formulation:Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:<0.1 EU/ug of the protein by LAL method.
Gene Symbol:Il21
Gene ID:60505
Uniprot ID:IL21_MOUSE
Immunogen:Recombinant Mouse IL-21 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His18-Ser146) of Mouse IL-21 (Accession #NP_068554.1) fused with a hFc tag at the C-terminus.
Immunogen Region:His18-Ser146
Immunogen Sequence:LQKKIEEIAAKYKHSVVKKC CYDGACVNNDETCEQRAARI SLGPRCIKAFTECCVVASQL RANISHKDMQLGR
Tissue Specificity Expressed in CD4(+) T cells.
Function Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Protein Name Interleukin-21
Il-21
Database Links Reactome: R-MMU-9020958
Cellular Localisation Secreted
Alternative Protein Names Interleukin-21 protein
Il-21 protein
Il21 protein

Information sourced from Uniprot.org

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