• Mouse IL-2 protein (Recombinant) (C-His) (STJP001375)
  • Mouse IL-2 protein (Recombinant) (C-His) (STJP001375)
  • Mouse IL-2 protein (Recombinant) (C-His) (STJP001375)
  • Mouse IL-2 protein (Recombinant) (C-His) (STJP001375)
  • Mouse IL-2 protein (Recombinant) (C-His) (STJP001375)
  • Mouse IL-2 protein (Recombinant) (C-His) (STJP001375)

Mouse IL-2 protein (Recombinant) (C-His) (STJP001375)

SKU:
STJP001375

Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse IL-2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Mouse IL-2 at 2 Mu g/mL (100 Mu L/well) can bind Mouse IL-2 with a linear range of 0.1-43.8 ng/mL.2. Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 for this
Gene Symbol: Il2
Gene ID: 16183
Uniprot ID: IL2_MOUSE
Immunogen: Recombinant Mouse IL-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala21-Gln169) of mouse IL2 (Accession #NP_032392.1) fused with a 6Ă—His tag at the C-terminus.
Function Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Protein Name Interleukin-2
Il-2
T-Cell Growth Factor
Tcgf
Cellular Localisation Secreted
Alternative Protein Names Interleukin-2 protein
Il-2 protein
T-Cell Growth Factor protein
Tcgf protein
Il2 protein
Il-2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance