| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | Il19 |
| Gene ID: | 329244 |
| Uniprot ID: | IL19_MOUSE |
| Immunogen Region: | Leu25-Ala176 |
| Immunogen: | Recombinant Mouse IL-19 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu25-Ala176) of Mouse IL-19 (Accession #NP_001009940.1) fused with a His tag at the C-terminus. |
| Immunogen Sequence: | CDLPQTHSLGNRRALILLAQ MGRISPFSCLKDRHDFGFPQ EEFDGNQFQKAQAISVLHEM IQQTFNLFSTKDSSATWEQS LLEKFSTELNQQLNDLEACV IQEVGVEETPLMNVDSILAV KKYFQRITLYLTEKKYSPCA WEVVRAEIMRSFSLSKIFQE RLRRKE |
| Function | Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL5. Produced by osteocytes, stimulates granulopoiesis and neutrophil formation. Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3. |
| Protein Name | Interleukin-19Il-19 |
| Database Links | Reactome: R-MMU-8854691 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-19 proteinIl-19 proteinIl19 protein |
Information sourced from Uniprot.org
