| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse IL-15RA/CD215-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human IL15 at 1 Mu g/mL (100 Mu L/well) can bind Mouse IL15RA with a linear range of 0.3-77 ng/mL. |
| Gene Symbol: |
Il15ra |
| Gene ID: |
16169 |
| Uniprot ID: |
I15RA_MOUSE |
| Immunogen: |
Recombinant Mouse IL-15RA/CD215 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly33-Lys205) of mouse IL15RA/CD215 (Accession #NP_032384.1) fused with a Fc, 6×His tag at the C-terminus. |
| Post Translational Modifications | N-glycosylated and O-glycosylated. A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. It also binds IL15 and thus interferes with IL15 binding to the membrane receptor. |
| Function | High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. |
| Protein Name | Interleukin-15 Receptor Subunit AlphaIl-15 Receptor Subunit AlphaIl-15r-AlphaIl-15raCd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit AlphaSil-15 Receptor Subunit AlphaSil-15r-AlphaSil-15ra |
| Database Links | Reactome: R-MMU-8983432 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinNucleus MembraneCell SurfaceSoluble Interleukin-15 Receptor Subunit Alpha: SecretedExtracellular Space |
| Alternative Protein Names | Interleukin-15 Receptor Subunit Alpha proteinIl-15 Receptor Subunit Alpha proteinIl-15r-Alpha proteinIl-15ra proteinCd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha proteinSil-15 Receptor Subunit Alpha proteinSil-15r-Alpha proteinSil-15ra proteinIl15ra protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
