Mouse IL-11 receptor alpha protein (Recombinant) (STJP000637)

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STJP000637
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse IL-11 receptor alpha-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution pH7.4.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was determined by its ability to bind mouse IL-6ST in functional ELISA. NA
Gene Symbol: Il11ra1
Gene ID: 16157
Uniprot ID: I11RA_MOUSE
Immunogen Region: ECD
Immunogen: DNA sequence encoding extracellular domain of Mouse IL-11RA fused to a C-terminal polyHis tag was expressed in HEK cells. NA
Immunogen Sequence: MSSSCSGLTR VLVAVATALV SSSSPCPQAW GPPGVQYGQP GRPVMLCCPG VSAGTPVSWF RDGDSRLLQG PDSGLGHRLV LAQVDSPDEG TYVCQTLDGV SGGMVTLKLG FPPARPEVSC QAVDYENFSC TWSPGQVSGL PTRYLTSYRK KTLPGAESQR ESPSTGPWPC PQDPLEASRC VVHGAEFWSE YRINVTEVNP LGASTCLLDV RLQSILRPDP PQGLRVES
Tissue Specificity Widely expressed in all adult tissues and in embryos. Highest levels in kidney, skeletal muscle and embryo.
Post Translational Modifications A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3.
Function Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Soluble interleukin-11 receptor subunit alpha: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
Protein Name Interleukin-11 Receptor Subunit Alpha-1
Il-11 Receptor Subunit Alpha-1
Il-11r Subunit Alpha-1
Il-11r-Alpha-1
Il-11ra1
Enhancer Trap Locus Homolog 2
Etl-2
Novel Cytokine Receptor 1
Nr-1
Nr1 Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha
Sil-11r
Sil-11ra
Sil11ra
Database Links Reactome: R-MMU-6788467
Cellular Localisation Interleukin-11 Receptor Subunit Alpha-1: Membrane
Single-Pass Type I Membrane Protein
Secreted
Soluble Interleukin-11 Receptor Subunit Alpha: Secreted
Alternative Protein Names Interleukin-11 Receptor Subunit Alpha-1 protein
Il-11 Receptor Subunit Alpha-1 protein
Il-11r Subunit Alpha-1 protein
Il-11r-Alpha-1 protein
Il-11ra1 protein
Enhancer Trap Locus Homolog 2 protein
Etl-2 protein
Novel Cytokine Receptor 1 protein
Nr-1 protein
Nr1 Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha protein
Sil-11r protein
Sil-11ra protein
Sil11ra protein
Il11ra1 protein
Etl2 protein
Il11ra protein

Information sourced from Uniprot.org

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