| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse IL-11 receptor alpha-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 Mu m filtered PBS solution pH7.4. |
| Dilution Range: |
Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: |
Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: |
The activity was determined by its ability to bind mouse IL-6ST in functional ELISA. NA |
| Gene Symbol: |
Il11ra1 |
| Gene ID: |
16157 |
| Uniprot ID: |
I11RA_MOUSE |
| Immunogen Region: |
ECD |
| Immunogen: |
DNA sequence encoding extracellular domain of Mouse IL-11RA fused to a C-terminal polyHis tag was expressed in HEK cells. NA |
| Immunogen Sequence: |
MSSSCSGLTR VLVAVATALV SSSSPCPQAW GPPGVQYGQP GRPVMLCCPG VSAGTPVSWF RDGDSRLLQG PDSGLGHRLV LAQVDSPDEG TYVCQTLDGV SGGMVTLKLG FPPARPEVSC QAVDYENFSC TWSPGQVSGL PTRYLTSYRK KTLPGAESQR ESPSTGPWPC PQDPLEASRC VVHGAEFWSE YRINVTEVNP LGASTCLLDV RLQSILRPDP PQGLRVES |
| Tissue Specificity | Widely expressed in all adult tissues and in embryos. Highest levels in kidney, skeletal muscle and embryo. |
| Post Translational Modifications | A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3. |
| Function | Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Soluble interleukin-11 receptor subunit alpha: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. |
| Protein Name | Interleukin-11 Receptor Subunit Alpha-1Il-11 Receptor Subunit Alpha-1Il-11r Subunit Alpha-1Il-11r-Alpha-1Il-11ra1Enhancer Trap Locus Homolog 2Etl-2Novel Cytokine Receptor 1Nr-1Nr1 Cleaved Into - Soluble Interleukin-11 Receptor Subunit AlphaSil-11rSil-11raSil11ra |
| Database Links | Reactome: R-MMU-6788467 |
| Cellular Localisation | Interleukin-11 Receptor Subunit Alpha-1: MembraneSingle-Pass Type I Membrane ProteinSecretedSoluble Interleukin-11 Receptor Subunit Alpha: Secreted |
| Alternative Protein Names | Interleukin-11 Receptor Subunit Alpha-1 proteinIl-11 Receptor Subunit Alpha-1 proteinIl-11r Subunit Alpha-1 proteinIl-11r-Alpha-1 proteinIl-11ra1 proteinEnhancer Trap Locus Homolog 2 proteinEtl-2 proteinNovel Cytokine Receptor 1 proteinNr-1 proteinNr1 Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha proteinSil-11r proteinSil-11ra proteinSil11ra proteinIl11ra1 proteinEtl2 proteinIl11ra protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
