Mouse IGF-I protein (Recombinant) (C-Avi&His) (STJP003020)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse IGF-I Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly49-Ala118) of Mouse IGF-I (Accession #NP_001104745.1) fused with a hFc tag at the N-terminus.
General Information
| Short Description | Recombinant-Mouse IGF-I-C-Avi&His protein was developed in hek293 cells using the region Gly49-Ala118. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.01 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | Igf1 |
| Gene ID | 16000 |
| Uniprot ID | IGF1_MOUSE |
| Immunogen | Recombinant Mouse IGF-I Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly49-Ala118) of Mouse IGF-I (Accession #NP_001104745.1) fused with a hFc tag at the N-terminus. |
| Immunogen Region | Gly49-Ala118 |
| Immunogen Sequence | APDVQDCPECTLQENPFFSQ PGAPILQCMGCCFSRAYPTP LRSKKTMLVQKNVTSESTCC VAKSYNRVTVMGGFKVENHT ACHCSTCYYHKS&SREPLRP WCHPINAILAVEKEGCPVCI TVNTTICAGYCPTMMRVLQA VLPPLPQVVCTYRDVRFESI RLPGCPRGVDPVVSFPVALS CRCGPCRRSTSDCGGPKDHP LTCDHPQLSGLLFL |
Additional Info
| Function | The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of 1-14C-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM. |
| Protein Name | Insulin-Like Growth Factor 1Insulin-Like Growth Factor IIgf-ISomatomedin |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-2404192Reactome: -MMU-2428928Reactome: -MMU-2428933Reactome: -MMU-381426Reactome: -MMU-422085 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Insulin-Like Growth Factor 1 proteinInsulin-Like Growth Factor I proteinIgf-I proteinSomatomedin proteinIgf1 proteinIgf-1 protein |
Information sourced from Uniprot.org