Mouse IGF-2 (Insulin-Like Growth Factor 2) Antibody Pair (STJAP00314)

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STJAP00314-50
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Host: Goat/Rat
Applications: ELISA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This IGF-2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Polyclonal/Monoclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Protein A or G.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: Igf2
Gene ID: 16002
Uniprot ID: IGF2_MOUSE
Immunogen: Capture immunogen: Recombinant Mouse IGF-2 protein.
Detection Immunogen: Recombinant Mouse IGF-2 protein.
Post Translational Modifications Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.
Function The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate. Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
Protein Name Insulin-Like Growth Factor 2
Insulin-Like Growth Factor Ii
Igf-Ii
Multiplication-Stimulating Polypeptide Cleaved Into - Preptin
Database Links Reactome: R-MMU-114608
Reactome: -MMU-2404192
Reactome: -MMU-2428928
Reactome: -MMU-2428933
Reactome: -MMU-381426
Cellular Localisation Secreted
Alternative Antibody Pair Names Insulin-Like Growth Factor 2 antibody pair
Insulin-Like Growth Factor Ii antibody pair
Igf-Ii antibody pair
Multiplication-Stimulating Polypeptide Cleaved Into - Preptin antibody pair
Igf2 antibody pair
Igf-2 antibody pair

Information sourced from Uniprot.org

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