Mouse IFN-Gamma R1 (Interferon Gamma Receptor 1) Antibody Pair (STJAP00106)
General Information
| Short Description | This IFN-Gamma R1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Rat/Goat |
| Reactivity | Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Polyclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Antigen Affinity. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Ifngr1 |
| Gene ID | 15979 |
| Uniprot ID | INGR1_MOUSE |
| Immunogen | Capture immunogen: Recombinant Mouse IFN-Gamma R1 protein.Detection Immunogen: Recombinant Mouse IFN-Gamma R1 protein. |
Additional Info
| Function | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1. |
| Protein Name | Interferon Gamma Receptor 1Ifn-Gamma Receptor 1Ifn-Gamma-R1Interferon Gamma Receptor Alpha-ChainIfn-Gamma-R-AlphaCd Antigen Cd119 |
| Database Links | Reactome: R-MMU-877300Reactome: -MMU-877312Reactome: -MMU-9732724 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | Interferon Gamma Receptor 1 antibody pairIfn-Gamma Receptor 1 antibody pairIfn-Gamma-R1 antibody pairInterferon Gamma Receptor Alpha-Chain antibody pairIfn-Gamma-R-Alpha antibody pairCd Antigen Cd119 antibody pairIfngr1 antibody pairIfngr antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse IFN-Gamma R1 (Interferon Gamma Receptor 1) Antibody Pair (STJAP00106)
This antibody pair detects mouse IFN-Gamma R1 (Interferon Gamma Receptor 1), corresponding to UniProt accession P15261. Reactivity is confirmed for mouse samples only.
Both antibodies are supplied at 0.5 mg/mL in PBS with 0.04% Proclin 300 and 50% glycerol at pH 7.4. The capture antibody is unconjugated, while the detection antibody is biotin-conjugated.
This pair has been validated for use in ELISA. No other assay formats are documented for this product.
The capture antibody is a rat-derived monoclonal antibody purified by Protein A or G, and the detection antibody is a goat-derived polyclonal antibody purified by antigen affinity. Both were raised against recombinant mouse IFN-Gamma R1 protein.
Both components should be stored at -20 degrees Celsius for long-term storage. Freeze-thaw cycles should be avoided to maintain reagent integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.