Mouse IFN-Gamma R1 (Interferon Gamma Receptor 1) Antibody Pair (STJAP00106)

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STJAP00106-50
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Host: Rat/Goat
Applications: ELISA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This IFN-Gamma R1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Clonality : Monoclonal/Polyclonal
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.
Purification: Capture Purification: Protein A or G.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: Ifngr1
Gene ID: 15979
Uniprot ID: INGR1_MOUSE
Immunogen: Capture immunogen: Recombinant Mouse IFN-Gamma R1 protein.
Detection Immunogen: Recombinant Mouse IFN-Gamma R1 protein.
Function Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (, PubMed:20926559, PubMed:27286456). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to its dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1.
Protein Name Interferon Gamma Receptor 1
Ifn-Gamma Receptor 1
Ifn-Gamma-R1
Interferon Gamma Receptor Alpha-Chain
Ifn-Gamma-R-Alpha
Cd Antigen Cd119
Database Links Reactome: R-MMU-877300
Reactome: -MMU-877312
Reactome: -MMU-9732724
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Pair Names Interferon Gamma Receptor 1 antibody pair
Ifn-Gamma Receptor 1 antibody pair
Ifn-Gamma-R1 antibody pair
Interferon Gamma Receptor Alpha-Chain antibody pair
Ifn-Gamma-R-Alpha antibody pair
Cd Antigen Cd119 antibody pair
Ifngr1 antibody pair
Ifngr antibody pair

Information sourced from Uniprot.org

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