Mouse HSP27 protein (Recombinant) (His-Tag) (STJP019411)
SPECIFICATIONS
HostE.coli
ImmunogenMouse
General Information
| Short Description | Recombinant-Mouse HSP27-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Hspb1 |
| Gene ID | 15507 |
| Uniprot ID | HSPB1_MOUSE |
| Accession Number | NP_038588 |
| Immunogen | Mouse |
| Immunogen Region | 1-209aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Phosphorylated upon exposure to protein kinase C activators and heat shock. Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement. |
| Function | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. |
| Protein Name | Heat Shock Protein Beta-1Hspb1Growth-Related 25 Kda ProteinHeat Shock 25 Kda ProteinHsp 25Heat Shock 27 Kda ProteinHsp 27P25 |
| Database Links | Reactome: R-MMU-4420097Reactome: -MMU-450408Reactome: -MMU-5687128Reactome: -MMU-9009391 |
| Cellular Localisation | CytoplasmNucleusCytoskeletonSpindleCytoplasmic In Interphase CellsColocalizes With Mitotic Spindles In Mitotic CellsTranslocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing Speckles |
| Alternative Protein Names | Heat Shock Protein Beta-1 proteinHspb1 proteinGrowth-Related 25 Kda Protein proteinHeat Shock 25 Kda Protein proteinHsp 25 proteinHeat Shock 27 Kda Protein proteinHsp 27 proteinP25 proteinHspb1 proteinHsp25 proteinHsp27 protein |
Information sourced from Uniprot.org