| Post Translational Modifications | Sumoylated. Phosphorylated on Ser-220 and Ser-450.which promotes 14-3-3-binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240 by DYRK1B.which impairs nuclear accumulation. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. |
| Function | Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter. |
| Protein Name | Histone Deacetylase 9Hd9Histone Deacetylase 7bHd7bHistone Deacetylase-Related ProteinMef2-Interacting Transcription Repressor Mitr |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Histone Deacetylase 9 proteinHd9 proteinHistone Deacetylase 7b proteinHd7b proteinHistone Deacetylase-Related Protein proteinMef2-Interacting Transcription Repressor Mitr proteinHdac9 proteinHdac7b proteinHdrp proteinMitr protein |
Information sourced from Uniprot.org
