Mouse GLI2 protein (Recombinant) (N-His) (STJP007389)
SPECIFICATIONS
HostE.coli
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse GLI2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | Gli2 |
| Gene ID | 14633 |
| Uniprot ID | GLI2_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Glu416-Gly570 |
Additional Info
| Function | Functions as a transcription regulator in the hedgehog (Hh) pathway. Functions as a transcriptional activator. May also function as transcriptional repressor. Requires STK36 for full transcriptional activator activity. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element. Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development. |
| Protein Name | Zinc Finger Protein Gli2Tax Helper Protein |
| Database Links | Reactome: R-MMU-5610787Reactome: -MMU-5632684 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionCiliumStk36 Promotes Translocation To The NucleusIn KeratinocytesIt Is Sequestered In The Cytoplasm By SufuIn The Absence Of SufuIt Translocates To The Nucleus |
| Alternative Protein Names | Zinc Finger Protein Gli2 proteinTax Helper Protein proteinGli2 proteinThp protein |
Information sourced from Uniprot.org