Name: Mouse GITR Ligand/TNFSF18 protein (Recombinant) (N-hFC) (STJP001986)
SKU: STJP001986
Availability: InStock

Mouse GITR Ligand/TNFSF18 protein (Recombinant) (N-hFC) (STJP001986)

SKU:

STJP001986

£97.50 - £291.50

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 0.1 EU/Mu g

Gene Symbol:	Tnfsf18
Gene ID:	240873
Uniprot ID:	TNF18_MOUSE
Immunogen Region:	Thr47-Ser173
Immunogen:	Recombinant Mouse GITR Ligand/TNFSF18 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr47-Ser173) of mouse GITR Ligand/TNFSF18 (Accession #NP_899247.3) fused with a hFc tag at the N-terminus.
Immunogen Sequence:	TAIESCMVKFELSSSKWHMT SPKPHCVNTTSDGKLKILQS GTYLIYGQVIPVDKKYIKDN APFVVQIYKKNDVLQTLMND FQILPIGGVYELHAGDNIYL KFNSKDHIQKTNTYWGIILM PDLPFIS

Post Translational Modifications	N-glycosylated.
Function	Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Protein Name	Tumor Necrosis Factor Ligand Superfamily Member 18 Gitr Ligand Gitrl Glucocorticoid-Induced Tnf-Related Ligand
Database Links	Reactome: R-MMU-5669034
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein
Alternative Protein Names	Tumor Necrosis Factor Ligand Superfamily Member 18 protein Gitr Ligand protein Gitrl protein Glucocorticoid-Induced Tnf-Related Ligand protein Tnfsf18 protein Gitrl protein

Information sourced from Uniprot.org

Model	Name	Host
STJP002766	Human GITR Ligand/TNFSF18 protein (Recombinant) (C-hFc) (STJP002766)	HEK293 cells
STJP001425	Human TNFSF18/GITR Ligand protein (Recombinant) (C-His) (STJP001425)	HEK293 cells
STJP001553	Human GITR Ligand/TNFSF18 Trimer protein (Recombinant) (N-His-Flag) {Biotin} (STJP001553)	HEK293
STJP002377	Mouse NKG2D/CD314 protein (Recombinant) (N-hFc) (STJP002377)	HEK293 cells
STJP001730	Mouse GDF15 protein (Recombinant) (N-hFc) {Biotin} (STJP001730)	HEK293

Mouse GITR Ligand/TNFSF18 protein (Recombinant) (N-hFC) (STJP001986)