| Tissue Specificity | |
| Post Translational Modifications | Acetylation of Lys-84 is observed in liver mitochondria from fasted mice but not from fed mice. ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity. Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer. |
| Function | Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. Plays a role in insulin homeostasis. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. |
| Protein Name | Glutamate Dehydrogenase 1 - MitochondrialGdh 1 |
| Database Links | Reactome: R-MMU-2151201Reactome: -MMU-8964539Reactome: -MMU-9837999 |
| Cellular Localisation | MitochondrionEndoplasmic ReticulumMostly Translocates Into The MitochondriaOnly A Small Amount Of The Protein Localizes To The Endoplasmic Reticulum |
| Alternative ELISA Names | Glutamate Dehydrogenase 1 - Mitochondrial ELISA kitGdh 1 ELISA kitGlud1 ELISA kitGlud ELISA kit |
| output | |
Information sourced from Uniprot.org
