| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Mouse FZD5-N-GST & C-His protein was developed from e.coli and has a target region of N-GST & C-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | Fzd5 |
| Gene ID: | 14367 |
| Uniprot ID: | FZD5_MOUSE |
| Immunogen Region: | Thr37-Ala126 |
| Immunogen: | Mus musculus (Mouse) |
| Post Translational Modifications | Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome. |
| Function | Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling. In neurons, activation by WNT7A promotes formation of synapses. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization. Plays a role in ocular development. |
| Protein Name | Frizzled-5Fz-5Mfz5 |
| Database Links | Reactome: R-MMU-4086398Reactome: -MMU-4608870Reactome: -MMU-4641262Reactome: -MMU-4641263Reactome: -MMU-5140745 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneSynapsePerikaryonCell ProjectionDendriteAxonLocalized At The Plasma Membrane And Also Found At The Golgi Apparatus |
| Alternative Protein Names | Frizzled-5 proteinFz-5 proteinMfz5 proteinFzd5 protein |
Information sourced from Uniprot.org