Mouse FZD5 protein (Recombinant) (N-GST & C-His) (STJP009928)

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STJP009928
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse FZD5-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Fzd5
Gene ID: 14367
Uniprot ID: FZD5_MOUSE
Immunogen Region: Thr37-Ala126
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.
Function Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling. In neurons, activation by WNT7A promotes formation of synapses. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization. Plays a role in ocular development.
Protein Name Frizzled-5
Fz-5
Mfz5
Database Links Reactome: R-MMU-4086398
Reactome: -MMU-4608870
Reactome: -MMU-4641262
Reactome: -MMU-4641263
Reactome: -MMU-5140745
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Synapse
Perikaryon
Cell Projection
Dendrite
Axon
Localized At The Plasma Membrane And Also Found At The Golgi Apparatus
Alternative Protein Names Frizzled-5 protein
Fz-5 protein
Mfz5 protein
Fzd5 protein

Information sourced from Uniprot.org

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