| Short Description : | Recombinant-Mouse FSTL3-C-His protein was developed in hek293 cells using the region Val24-Val256. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | Fstl3 |
| Gene ID: | 83554 |
| Uniprot ID: | FSTL3_MOUSE |
| Immunogen: | Recombinant Mouse FSTL3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val24-Val256) of Mouse FSTL3 (Accession #Q9EQC7) fused with His tag at the C-terminus. |
| Immunogen Region: | Val24-Val256 |
| Immunogen Sequence: | VMGSEDSVPGGVCWLQQGRE ATCSLVLKTRVSREECCASG NINTAWSNFTHPGNKISLLG FLGLVHCLPCKDSCDGVECG PGKACRMLGGRPHCECVPNC EGLPAGFQVCGSDGATYRDE CELRTARCRGHPDLRVMYRG RCQKSCAQVVCPRPQSCLVD QTGSAHCVVCRAAPCPVPSN PGQELCGNNNVTYISSCHLR QATCFLGRSIGVRHPGICTG GPKVPAEEEENFV |
| Tissue Specificity | Abundantly expressed in heart, lung, kidney and testis. Continuously expressed in embryonic heart. |
| Function | The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling.more effective on activin A than on activin B. Involved in bone formation.inhibits osteoclast differentiation. Involved in hematopoiesis.involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. |
| Protein Name | Follistatin-Related Protein 3Follistatin-Like Protein 3Follistatin-Related Gene Protein |
| Database Links | Reactome: R-MMU-2473224Reactome: -MMU-381426Reactome: -MMU-8957275 |
| Cellular Localisation | SecretedNucleus |
| Alternative Protein Names | Follistatin-Related Protein 3 proteinFollistatin-Like Protein 3 proteinFollistatin-Related Gene Protein proteinFstl3 proteinFlrg protein |
Information sourced from Uniprot.org
