| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse Fc-gamma RIIB/CD32b-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Gene Symbol: |
Fcgr2 |
| Gene ID: |
14130 |
| Uniprot ID: |
FCGR2_MOUSE |
| Immunogen: |
Recombinant Mouse Fc-gamma RIIB/CD32b Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr30-Pro210) of mouse Fc gamma RIIB/CD32b (Accession #NP_034317.1) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | Glycosylated. When coaggregated to BCR, isoform IIB1 and isoform IIB1' become tyrosine phosphorylated and bind to the SH2 domains of the protein tyrosine phosphatase PTPC1. Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK. |
| Function | Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively. |
| Protein Name | Low Affinity Immunoglobulin Gamma Fc Region Receptor IiFc Gamma Receptor IibFc-Gamma RiiFc-Gamma-RiibFcriiIgg Fc Receptor Ii BetaLymphocyte Antigen 17Ly-17Cd Antigen Cd32 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-2029481Reactome: -MMU-2029482Reactome: -MMU-2029485Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Iib1: CytoplasmCytoskeletonBinds The Cytoskeleton And Is Not Localized In Endocytotic PitsIsoform Iib3: SecretedReleased As A Soluble Molecule |
| Alternative Protein Names | Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii proteinFc Gamma Receptor Iib proteinFc-Gamma Rii proteinFc-Gamma-Riib proteinFcrii proteinIgg Fc Receptor Ii Beta proteinLymphocyte Antigen 17 proteinLy-17 proteinCd Antigen Cd32 proteinFcgr2 proteinFcgr2b proteinLy-17 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
