| Host: | Mammalian Cells |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Mouse F10/Factor X-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilized from a 0.22 Mu m filtered solution in 20mM MES, 150mM NaCl, 1mM CaCl2, pH 7.5. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | < 1 EU/µg as determined by LAL test. |
| Gene Symbol: | F10 |
| Gene ID: | 14058 |
| Uniprot ID: | FA10_MOUSE |
| Immunogen Region: | Gly21-Asn481 |
| Immunogen: | Mus musculus (Mouse) |
| Post Translational Modifications | The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. N- and O-glycosylated. Proteolytically cleaved and activated by cathepsin CTSG. The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). |
| Function | Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Factor Xa activates pro-inflammatory and pro-fibrotic signaling pathways in a protease-activated receptor (PAR)-dependent manner. |
| Protein Name | Coagulation Factor XStuart Factor Cleaved Into - Factor X Light Chain - Factor X Heavy Chain - Activated Factor Xa Heavy Chain |
| Database Links | Reactome: R-MMU-140834Reactome: -MMU-140837Reactome: -MMU-140875Reactome: -MMU-159740Reactome: -MMU-159763Reactome: -MMU-159782 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Coagulation Factor X proteinStuart Factor Cleaved Into - Factor X Light Chain - Factor X Heavy Chain - Activated Factor Xa Heavy Chain proteinF10 protein |
Information sourced from Uniprot.org
