Mouse EREG protein (Recombinant) (N-HuFc-His) (STJP002955)

SKU:
STJP002955

Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured in a cell proliferation assay using Balb3T3 mouse fibroblast cells. The ED50 for this effect is 140.58-562.31 ng/mL, corresponding to a specific activity of 1.78×103~7.11×103 units/mg.
Gene Symbol: Ereg
Gene ID: 13874
Uniprot ID: EREG_MOUSE
Immunogen Region: Val56-Leu101 
Immunogen: Recombinant Mouse EREG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val56-Leu101 ) of Mouse EREG (Accession #NP_031976.1) fused with hFc tag at the N-terminus.
Immunogen Sequence: QDGSVLSVPGPEGRPGFAGF PGPAGPKGNLGSKGERGSPG PKGEKGEPGSIFSPDGGALG PAQKGAKGEPGFRGPPGPYG RPGYKGEIGFPGRPGRPGMN GLKGEKGEPGDASLGFGMRG MPGPPGPPGPPGPPGTPVYD SNVFAESSRPGPPGLPGNQG PPGPKGAKGEVGPPGPPGQF PFDFLQLEAEMKGEKGDRGD AGQKGERGEPGGGGFFGSSL PGPPGPPGPPGPRGYPGIP
Function Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.
Protein Name Proepiregulin Cleaved Into - Epiregulin
Epr
Database Links Reactome: R-MMU-1227986
Reactome: -MMU-1236394
Reactome: -MMU-1250196
Reactome: -MMU-1250342
Reactome: -MMU-1250347
Reactome: -MMU-1257604
Reactome: -MMU-177929
Reactome: -MMU-179812
Reactome: -MMU-180292
Reactome: -MMU-180336
Reactome: -MMU-182971
Reactome: -MMU-1963640
Reactome: -MMU-1963642
Reactome: -MMU-212718
Reactome: -MMU-5673001
Reactome: -MMU-6785631
Reactome: -MMU-6811558
Reactome: -MMU-8847993
Reactome: -MMU-8856825
Reactome: -MMU-8856828
Reactome: -MMU-8863795
Reactome: -MMU-9009391
Cellular Localisation Epiregulin: Secreted
Extracellular Space
Proepiregulin: Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Proepiregulin Cleaved Into - Epiregulin protein
Epr protein
Ereg protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance