| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Mouse EFNA2 Protein at 2 Mu g/mL (100 Mu L/well) can bind Mouse EphA4 with a linear range of 4.88-129.3 ng/mL. |
| Gene Symbol: |
Efna2 |
| Gene ID: |
13637 |
| Uniprot ID: |
EFNA2_MOUSE |
| Immunogen: |
Recombinant Mouse Ephrin-A2/EFNA2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg21-Asn184) of mouse Ephrin-A2 (Accession #NP_031935.3) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
RNEDPARANADRYAVYWNRS NPRFQVSAVGDGGGYTVEVS INDYLDIYCPHYGAPLPPAE RMERYILYMVNGEGHASCDH RQRGFKRWECNRPAAPGGPL KFSEKFQLFTPFSLGFEFRP GHEYYYISATPPNLVDRPCL RLKVYVRPTNETLYEAPEPI FTSN |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. |
| Protein Name | Ephrin-A2Cek7-LigandCek7-LElf-1Eph-Related Receptor Tyrosine Kinase Ligand 6Lerk-6 |
| Database Links | Reactome: R-MMU-2682334Reactome: -MMU-3928663Reactome: -MMU-3928665 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Protein Names | Ephrin-A2 proteinCek7-Ligand proteinCek7-L proteinElf-1 proteinEph-Related Receptor Tyrosine Kinase Ligand 6 proteinLerk-6 proteinEfna2 proteinElf1 proteinEpl6 proteinEplg6 proteinLerk6 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
