| Post Translational Modifications | N-Glycosylated. |
| Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Participates in the formation of certain VLCFA and triglycerides in certain cells of the hair follicles and the sebaceous glands, required for skin barrier function. Critical enzyme for lipid accumulation and metabolic activity in brown adipocytes during the early phase of the tissue recruitment. Plays a role in lipid storage and in resistance to diet-induced obesity. |
| Protein Name | Very Long Chain Fatty Acid Elongase 33-Keto Acyl-Coa Synthase Elovl3Cin-2Cold-Inducible Glycoprotein Of 30 KdaElovl Fatty Acid Elongase 3Elovl Fa Elongase 3Elongation Of Very Long Chain Fatty Acids Protein 3Very Long Chain 3-Ketoacyl-Coa Synthase 3Very Long Chain 3-Oxoacyl-Coa Synthase 3 |
| Database Links | Reactome: R-MMU-2046105Reactome: -MMU-2046106Reactome: -MMU-75876 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Very Long Chain Fatty Acid Elongase 3 protein3-Keto Acyl-Coa Synthase Elovl3 proteinCin-2 proteinCold-Inducible Glycoprotein Of 30 Kda proteinElovl Fatty Acid Elongase 3 proteinElovl Fa Elongase 3 proteinElongation Of Very Long Chain Fatty Acids Protein 3 proteinVery Long Chain 3-Ketoacyl-Coa Synthase 3 proteinVery Long Chain 3-Oxoacyl-Coa Synthase 3 proteinElovl3 proteinCig30 protein |
Information sourced from Uniprot.org
