Function | Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. |
Protein Name | Ets Homologous FactorEts Domain-Containing Transcription Factor |
Cellular Localisation | Nucleus |
Alternative Protein Names | Ets Homologous Factor proteinEts Domain-Containing Transcription Factor proteinEhf protein |
Information sourced from Uniprot.org