Mouse EFNA5 protein (Recombinant) (C-His) (STJP015572)
SPECIFICATIONS
HostMammalian Cells
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse EFNA5-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | Efna5 |
| Gene ID | 13640 |
| Uniprot ID | EFNA5_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Gln21-Asn203 |
Additional Info
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion. |
| Protein Name | Ephrin-A5Al-1Eph-Related Receptor Tyrosine Kinase Ligand 7Lerk-7 |
| Database Links | Reactome: R-MMU-2682334Reactome: -MMU-3928663Reactome: -MMU-3928665 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembraneCaveolaCompartmentalized In Discrete Caveolae-Like Membrane Microdomains |
| Alternative Protein Names | Ephrin-A5 proteinAl-1 proteinEph-Related Receptor Tyrosine Kinase Ligand 7 proteinLerk-7 proteinEfna5 proteinEpl7 proteinEplg7 proteinLerk7 protein |
Information sourced from Uniprot.org