| Tissue Specificity | Expressed in liver (at protein level). |
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction. |
| Protein Name | Dihydrolipoyl Dehydrogenase - MitochondrialDihydrolipoamide Dehydrogenase |
| Database Links | Reactome: R-MMU-204174Reactome: -MMU-5362517Reactome: -MMU-6783984Reactome: -MMU-70895Reactome: -MMU-9837999Reactome: -MMU-9853506Reactome: -MMU-9858328Reactome: -MMU-9859138Reactome: -MMU-9861559 |
| Cellular Localisation | Mitochondrion MatrixNucleusCell ProjectionCiliumFlagellumCytoplasmic VesicleSecretory VesicleAcrosomeMainly Localizes In The MitochondrionA Small Fraction Localizes To The NucleusWhere The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation |
| Alternative ELISA Names | Dihydrolipoyl Dehydrogenase - Mitochondrial ELISA kitDihydrolipoamide Dehydrogenase ELISA kitDld ELISA kit |
| output | |
Information sourced from Uniprot.org
