Tissue Specificity | |
Post Translational Modifications | |
Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. |
Protein Name | Dickkopf-Related Protein 4Dickkopf-4Dkk-4 |
Database Links | Reactome: R-MMU-3772470 |
Cellular Localisation | Secreted |
Alternative ELISA Names | Dickkopf-Related Protein 4 ELISA kitDickkopf-4 ELISA kitDkk-4 ELISA kitDkk4 ELISA kit |
output | |
Information sourced from Uniprot.org