• Mouse Dkk-1 protein (Recombinant) (C-His) (STJP001341)
  • Mouse Dkk-1 protein (Recombinant) (C-His) (STJP001341)
  • Mouse Dkk-1 protein (Recombinant) (C-His) (STJP001341)
  • Mouse Dkk-1 protein (Recombinant) (C-His) (STJP001341)

Mouse Dkk-1 protein (Recombinant) (C-His) (STJP001341)

SKU:
STJP001341

Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM Tris, 500mM NaCl, 10% Glycerol, pH 8.0.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its binding ability in a functional ELISA.Immobilized Mouse DKK-1 at 5 Mu g/mL (100 Mu L/well) can bind Human LRP-5 with a linear range of 0.001-0.623 Mu g/mL.
Gene Symbol: Dkk1
Gene ID: 13380
Uniprot ID: DKK1_MOUSE
Immunogen Region: Thr32-His272
Immunogen: Recombinant Mouse Dkk-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr32-His272) of mouse DKK-1 (Accession #NP_034181.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: TLNSVLINSNAIKNLPPPLG GAGGQPGSAVSVAPGVLYEG GNKYQTLDNYQPYPCAEDEE CGSDEYCSSPSRGAAGVGGV QICLACRKRRKRCMRHAMCC PGNYCKNGICMPSDHSHFPR GEIEESIIENLGNDHNAAAG DGYPRRTTLTSKIYHTKGQE GSVCLRSSDCAAGLCCARHF WSKICKPVLKEGQVCTKHKR KGSHGLEIFQRCYCGEGLAC RIQKDHHQASNSSRLHTCQ
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Plays a role in limb development.attenuates Wnt signaling in the developing limb to allow normal limb patterning.
Protein Name Dickkopf-Related Protein 1
Dickkopf-1
Dkk-1
Mdkk-1
Database Links Reactome: R-MMU-3772470
Cellular Localisation Secreted
Alternative Protein Names Dickkopf-Related Protein 1 protein
Dickkopf-1 protein
Dkk-1 protein
Mdkk-1 protein
Dkk1 protein

Information sourced from Uniprot.org

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