| Host: |
Pichia |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse CXCL10/IP-10-No tag protein was developed from pichia and has a target region of No tag. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Cxcl10 |
| Gene ID: |
15945 |
| Uniprot ID: |
CXL10_MOUSE |
| Immunogen Region: |
Ile22-Pro98 |
| Immunogen: |
Recombinant Mouse CXCL10/IP-10 Protein is produced by Pichia expression system. The target protein is expressed with sequence (Ile22-Pro98) of mouse CXCL10/IP-10 (Accession #NP_067249.1) fused with no additional amino acid. |
| Function | Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization. |
| Protein Name | C-X-C Motif Chemokine 1010 Kda Interferon Gamma-Induced ProteinGamma-Ip10Ip-10C7Interferon-Gamma Induced Protein Crg-2Small-Inducible Cytokine B10 |
| Database Links | Reactome: R-MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-X-C Motif Chemokine 10 protein10 Kda Interferon Gamma-Induced Protein proteinGamma-Ip10 proteinIp-10 proteinC7 proteinInterferon-Gamma Induced Protein Crg-2 proteinSmall-Inducible Cytokine B10 proteinCxcl10 proteinCrg2 proteinIfi10 proteinInp10 proteinScyb10 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
