| Post Translational Modifications | During export along the endocytic pathway, pro-CTSL undergoes several proteolytic cleavages to generate the CTSL single-chain and two-chain mature forms, composed of a heavy chain linked to a light chain by disulfide bonds. Autocleavage.produces the single-chain CTSL after cleavage of the propeptide. The cleavage can be intermolecular. |
| Function | Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter. In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells. Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation. Secreted form generates endostatin from COL18A1. Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation. Required for maximal stimulation of steroidogenesis by TIMP1. |
| Protein Name | Procathepsin LCathepsin L1Major Excreted ProteinMepP39 Cysteine Proteinase Cleaved Into - Cathepsin L - Cathepsin L Heavy Chain - Cathepsin L Light Chain |
| Database Links | Reactome: R-MMU-1474228Reactome: -MMU-1592389Reactome: -MMU-1679131Reactome: -MMU-2022090Reactome: -MMU-2132295Reactome: -MMU-8939242 |
| Cellular Localisation | LysosomeApical Cell MembranePeripheral Membrane ProteinExtracellular SideSecretedExtracellular SpaceCytoplasmic VesicleSecretory VesicleChromaffin GranuleLocalizes To The Apical Membrane Of Thyroid Epithelial CellsReleased At Extracellular Space By Activated Dendritic Cells And Macrophages |
| Alternative Antibody Pair Names | Procathepsin L antibody pairCathepsin L1 antibody pairMajor Excreted Protein antibody pairMep antibody pairP39 Cysteine Proteinase Cleaved Into - Cathepsin L - Cathepsin L Heavy Chain - Cathepsin L Light Chain antibody pairCtsl antibody pairCtsl1 antibody pair |
Information sourced from Uniprot.org
