Mouse Crystallin alpha B/CRYAB protein (Recombinant) (No-Tag) (STJP019598)
SPECIFICATIONS
HostE.coli
ImmunogenMouse
General Information
| Short Description | Recombinant-Mouse Crystallin alpha B/CRYAB-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10 % Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Cryab |
| Gene ID | 12955 |
| Uniprot ID | CRYAB_MOUSE |
| Accession Number | NP_034094.1 |
| Immunogen | Mouse |
| Immunogen Region | 1-175aa |
| Immunogen Sequence | MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFST ATSLSPFYLR PPSFLRAPSW IDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVA AAPKK |
Additional Info
| Tissue Specificity | Abundantly expressed in the lens of the eye. Expressed in ventricular cardiomyocytes of the heart. Also expressed in skeletal muscle and the kidney. |
| Function | May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome. |
| Protein Name | Alpha-Crystallin B ChainAlpha(B-CrystallinP23 |
| Database Links | Reactome: R-MMU-3371571 |
| Cellular Localisation | CytoplasmCytosolNucleusSecretedLysosomeTranslocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing SpecklesLocalizes At The Z-Bands And The Intercalated Disk In CardiomyocytesCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Protein Names | Alpha-Crystallin B Chain proteinAlpha(B-Crystallin proteinP23 proteinCryab proteinCrya2 protein |
Information sourced from Uniprot.org